The safety and efficacy of BEPREVE® have not been established in pediatric patients under 3 years of age
Efficacy of BEPREVE® in pediatric patients with age < 10 was extrapolated from clinical trials conducted in pediatric patients with age >10 and in adults
Relevant warnings and precautions:
For topical ophthalmic use only
Do not touch the eyelids or surrounding areas with the dropper tip of the bottle and keep bottle tightly closed when not in use
Do not use to treat contact lens-related irritation
Do not instill while wearing contact lenses. Lenses may be reinserted after 10 minutes following administration.
Should not be used in pregnant women unless the benefit to the mother justifies the potential risk to the fetus
BEPREVE®: a second-generation dual-acting antihistamine with several described mechanisms of action that play a role in the allergic response1†
01
Selective H1 receptor-antagonist
02
Stabilization of mast cell
03
Inhibitory action on eosinophilic migration to inflammatory sites
04
Suppression of vascular permeability
Adapted from Product Monograph1
Adapted from Product Monograph1
BEPREVE® inhibits the production of interleukin-5 (IL-5), a key factor in eosinophil activation, as well as other mediators of inflammatory and allergic reactions such as leukotriene B4 (LTB4), leukotriene D4 (LTD4), platelet activating factor (PAF) and substance P.
BEPREVE® demonstrates activity in both early and late phases of the allergic response