Mechanism of Action

BEPREVE®: a second-generation dual-acting antihistamine with several described mechanisms of action that play a role in the allergic response1†

01

Selective H1 receptor-antagonist

02

Stabilization of mast cell

03

Inhibitory action on eosinophilic migration to inflammatory sites

04

Suppression of vascular permeability
Adapted from Product Monograph1
Monograph
Adapted from Product Monograph1

BEPREVE® inhibits the production of interleukin-5 (IL-5), a key factor in eosinophil activation, as well as other mediators of inflammatory and allergic reactions such as leukotriene B4 (LTB4), leukotriene D4 (LTD4), platelet activating factor (PAF) and substance P.

BEPREVE® demonstrates activity in both early and late phases of the allergic response

Clinical significance has not been established.